{"lab": {"@type": ["Lab", "Item"], "status": "current", "title": "Rafael Casellas, NIH", "correspondence": [{"contact_email": "Y2FzZWxsYXJAbWFpbC5uaWguZ292", "@id": "/users/68b09572-0c3e-48c7-90a9-7bad21d6bac1/", "display_title": "Rafael Casellas"}], "uuid": "ce54a7f7-af8a-4505-8327-e430634f494b", "display_title": "Rafael Casellas, NIH", "@id": "/labs/rafael-casellas-lab/", "pi": {"error": "no view permissions"}, "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin", "role.lab_submitter", "submits_for.ce54a7f7-af8a-4505-8327-e430634f494b"]}}, "award": {"description": "Funding source is from outside 4DN.", "project": "External", "status": "current", "@type": ["Award", "Item"], "name": "external-award", "center_title": "External", "display_title": "EXTERNAL AWARD", "uuid": "12a92962-8265-4fc0-b2f8-cf14f05db58b", "center": "External", "@id": "/awards/external-award/", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "status": "released", "aliases": ["4dn-dcic-lab:SAMN09112121"], "dbxrefs": ["BioSample:SAMN09112121", "ENCODE:ENCBS686LQK"], "accession": "4DNBS7NCTWBB", "biosource": [{"lab": {"display_title": "4DN DCIC, HMS", "uuid": "828cd4fe-ebb0-4b36-a94a-d2e3a36cc989", "@id": "/labs/4dn-dcic-lab/", "status": "current", "@type": ["Lab", "Item"], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin", "role.lab_submitter", "submits_for.828cd4fe-ebb0-4b36-a94a-d2e3a36cc989"]}}, "award": {"status": "current", "display_title": "4D NUCLEOME NETWORK DATA COORDINATION AND INTEGRATION CENTER - PHASE I", "uuid": "b0b9c607-f8b4-4f02-93f4-9895b461334b", "@type": ["Award", "Item"], "@id": "/awards/1U01CA200059-01/", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "status": "released", "tissue": {"display_title": "splenocyte", "term_name": "splenocyte", "term_id": "CL:2000074", "@id": "/ontology-terms/CL:2000074/", "status": "released", "term_url": "http://purl.obolibrary.org/obo/CL_2000074", "preferred_name": "splenocyte", "@type": ["OntologyTerm", "Item"], "uuid": "94bbfc93-633a-450a-92d9-261c13d3548a", "slim_terms": [{"uuid": "111177bc-8535-4448-903e-854af460a233", "preferred_name": "spleen", "status": "released", "@type": ["OntologyTerm", "Item"], "term_url": "http://purl.obolibrary.org/obo/UBERON_0002106", "term_id": "UBERON:0002106", "@id": "/ontology-terms/UBERON:0002106/", "term_name": "spleen", "synonyms": ["lien", "Entire spleen"], "display_title": "spleen", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"uuid": "111133bc-8535-4448-903e-854af460a233", "preferred_name": "immune system", "status": "released", "@type": ["OntologyTerm", "Item"], "term_url": "http://purl.obolibrary.org/obo/UBERON_0002405", "term_id": "UBERON:0002405", "@id": "/ontology-terms/UBERON:0002405/", "term_name": "immune system", "display_title": "immune system", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"uuid": "111120bc-8535-4448-903e-854af460a233", "preferred_name": "mesoderm", "status": "released", "@type": ["OntologyTerm", "Item"], "term_url": "http://purl.obolibrary.org/obo/UBERON_0000926", "term_id": "UBERON:0000926", "@id": "/ontology-terms/UBERON:0000926/", "term_name": "mesoderm", "synonyms": ["entire mesoderm", "embryonic mesoderm", "mesodermal mantle", "Entire mesoderm"], "display_title": "mesoderm", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"uuid": "111129bc-8535-4448-903e-854af460a233", "preferred_name": "digestive system", "status": "released", "@type": ["OntologyTerm", "Item"], "term_url": "http://purl.obolibrary.org/obo/UBERON_0001007", "term_id": "UBERON:0001007", "@id": "/ontology-terms/UBERON:0001007/", "term_name": "digestive system", "synonyms": ["alimentary tract", "alimentary system", "Entire digestive system", "gut", "gastrointestinal system"], "display_title": "digestive system", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"uuid": "72e16a19-eef3-46ca-a1b8-20e646e69675", "preferred_name": "cell", "status": "current", "@type": ["OntologyTerm", "Item"], "term_url": "http://purl.obolibrary.org/obo/GO_0005623", "term_id": "GO:0005623", "@id": "/ontology-terms/GO:0005623/", "term_name": "cell", "display_title": "cell", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"uuid": "45d2b02e-130b-40db-8bf2-2288c6c57dcf", "preferred_name": "cell", "status": "released", "@type": ["OntologyTerm", "Item"], "term_url": "http://purl.obolibrary.org/obo/CL_0000000", "term_id": "CL:0000000", "@id": "/ontology-terms/CL:0000000/", "term_name": "cell", "display_title": "cell", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "aliases": ["4dn-dcic-lab:biosource-Vian-mouse-B-cells"], "accession": "4DNSRA3JY5KY", "cell_line": {"preferred_name": "B cell derived cell line", "term_name": "B cell derived cell line", "status": "released", "@id": "/ontology-terms/EFO:0001640/", "term_id": "EFO:0001640", "uuid": "a35ee804-9776-45b2-8b66-d29b00558c8d", "term_url": "http://www.ebi.ac.uk/efo/EFO_0001640", "@type": ["OntologyTerm", "Item"], "display_title": "B cell derived cell line", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "individual": {"sex": "unknown", "@id": "/individuals-mouse/4DNIN9IKCB4R/", "@type": ["IndividualMouse", "Individual", "Item"], "uuid": "408b84a5-aaa6-4d79-81d8-c3b6ba280f49", "status": "released", "display_title": "4DNIN9IKCB4R", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, "description": "Resting splenic B cells were isolated from 6-8 weeks old C57BL6/J mouse spleen by negative selection (Stemcell technologies)", "date_created": "2018-11-27T16:42:09.530809+00:00", "submitted_by": {"error": "no view permissions"}, "last_modified": {"modified_by": {"error": "no view permissions"}, "date_modified": "2019-11-25T02:46:36.434313+00:00"}, "biosource_type": "primary cell", "cell_line_tier": "Unclassified", "public_release": "2019-11-25", "schema_version": "2", "project_release": "2019-11-25", "@id": "/biosources/4DNSRA3JY5KY/", "@type": ["Biosource", "Item"], "uuid": "469a5e58-d40f-4536-8df9-5c603111ba1f", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "display_title": "B cell derived cell line - 4DNSRA3JY5KY", "external_references": [], "biosource_name": "B cell derived cell line", "biosource_category": ["Primary Cells"], "organism": {"@id": "/organisms/10090/", "uuid": "3413218c-3d86-498b-a0a2-9a406638e786", "status": "released", "@type": ["Organism", "Item"], "name": "mouse", "display_title": "M. musculus", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}}], "treatments": [{"duration_units": "hour", "@id": "/treatments-agent/4a1c97ad-a383-46a0-bd14-e160f3945331/", "status": "released", "treatment_type": "Chemical", "@type": ["TreatmentAgent", "Treatment", "Item"], "display_title": "LPS (Sigma) treatment (50.0 \u03bcg/mL, 24.0h)", "concentration": 50.0, "concentration_units": "\u03bcg/mL", "duration": 24.0, "chemical": "LPS (Sigma)", "uuid": "4a1c97ad-a383-46a0-bd14-e160f3945331", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"duration_units": "hour", "@id": "/treatments-agent/6dfad8ce-dd21-407d-8690-107a2227f41a/", "status": "released", "treatment_type": "Chemical", "@type": ["TreatmentAgent", "Treatment", "Item"], "display_title": "IL-4 (Sigma) treatment (2.5 ng/mL, 24.0h)", "concentration": 2.5, "concentration_units": "ng/mL", "duration": 24.0, "chemical": "IL-4 (Sigma)", "uuid": "6dfad8ce-dd21-407d-8690-107a2227f41a", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"duration_units": "hour", "@id": "/treatments-agent/8b005c43-4555-4393-ae0e-93d93625b08f/", "status": "released", "treatment_type": "Chemical", "@type": ["TreatmentAgent", "Treatment", "Item"], "display_title": "anti-CD180 (RP105) antibody, BD PharMingen treatment (0.5 \u03bcg/mL, 24.0h)", "concentration": 0.5, "concentration_units": "\u03bcg/mL", "duration": 24.0, "chemical": "anti-CD180 (RP105) antibody, BD PharMingen", "uuid": "8b005c43-4555-4393-ae0e-93d93625b08f", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"duration_units": "hour", "@id": "/treatments-agent/0ceef4ff-dddb-47b7-8302-09a6689e760d/", "status": "released", "treatment_type": "Chemical", "@type": ["TreatmentAgent", "Treatment", "Item"], "display_title": "flavopiridol treatment (1.0 \u03bcM, 4.0h)", "concentration": 1.0, "concentration_units": "\u03bcM", "duration": 4.0, "chemical": "flavopiridol", "uuid": "0ceef4ff-dddb-47b7-8302-09a6689e760d", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "description": "24 hour activated B cells, treated with flavopiridol (4 hour) to inhibit transcription", "date_created": "2018-11-27T17:36:22.013521+00:00", "submitted_by": {"error": "no view permissions"}, "last_modified": {"modified_by": {"error": "no view permissions"}, "date_modified": "2020-08-25T22:28:46.909851+00:00"}, "public_release": "2019-11-25", "schema_version": "2", "project_release": "2019-11-25", "@id": "/biosamples/4DNBS7NCTWBB/", "@type": ["Biosample", "Item"], "uuid": "49920318-134f-4df7-94e3-b0d14db65994", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}, "display_title": "4DNBS7NCTWBB", "external_references": [{"ref": "BioSample:SAMN09112121", "uri": "https://www.ncbi.nlm.nih.gov/biosample/SAMN09112121"}, {"ref": "ENCODE:ENCBS686LQK", "uri": "https://www.encodeproject.org/ENCBS686LQK"}], "modifications_summary": "None", "modifications_summary_short": "None", "treatments_summary": "LPS (Sigma) treatment (50.0 \u03bcg/mL, 24.0h) and IL-4 (Sigma) treatment (2.5 ng/mL, 24.0h) and anti-CD180 (RP105) antibody, BD PharMingen treatment (0.5 \u03bcg/mL, 24.0h) and flavopiridol treatment (1.0 \u03bcM, 4.0h)", "tissue_organ_info": {"tissue_source": "splenocyte", "organ_system": ["spleen", "immune system", "mesoderm", "digestive system"]}, "biosource_summary": "B cell derived cell line", "biosample_type": "primary cells", "biosample_category": ["Primary Cells"], "@context": "/terms/", "aggregated-items": {"badges": []}, "validation-errors": []}