{"status": "released", "parents": [{"preferred_name": "ESC derived cell line", "term_url": "http://www.ebi.ac.uk/efo/EFO_0005738", "@id": "/ontology-terms/EFO:0005738/", "@type": ["OntologyTerm", "Item"], "uuid": "b83d9e9c-64d7-4c24-881b-64117aad2a20", "status": "released", "display_title": "ESC derived cell line", "term_name": "ESC derived cell line", "term_id": "EFO:0005738", "source_ontologies": [{"@id": "/ontologys/530006bc-8535-4448-903e-854af460b254/", "@type": ["Ontology", "Item"], "ontology_name": "Experimental Factor Ontology", "uuid": "530006bc-8535-4448-903e-854af460b254", "display_title": "Experimental Factor Ontology", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"preferred_name": "Homo sapiens cell line", "term_url": "http://www.ebi.ac.uk/efo/EFO_0002888", "@id": "/ontology-terms/EFO:0002888/", "@type": ["OntologyTerm", "Item"], "uuid": "ba0db777-83bc-4bc4-beb5-f37f2828ad5c", "status": "released", "display_title": "Homo sapiens cell line", "term_name": "Homo sapiens cell line", "term_id": "EFO:0002888", "source_ontologies": [{"@id": "/ontologys/530006bc-8535-4448-903e-854af460b254/", "@type": ["Ontology", "Item"], "ontology_name": "Experimental Factor Ontology", "uuid": "530006bc-8535-4448-903e-854af460b254", "display_title": "Experimental Factor Ontology", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}, {"preferred_name": "embryonic cell line", "term_url": "http://www.ebi.ac.uk/efo/EFO_0003040", "@id": "/ontology-terms/EFO:0003040/", "@type": ["OntologyTerm", "Item"], "uuid": "e99de3e8-531e-4578-9a70-0f0893813311", "status": "released", "display_title": "embryonic cell line", "term_name": "embryonic cell line", "term_id": "EFO:0003040", "source_ontologies": [{"@id": "/ontologys/530006bc-8535-4448-903e-854af460b254/", "@type": ["Ontology", "Item"], "ontology_name": "Experimental Factor Ontology", "uuid": "530006bc-8535-4448-903e-854af460b254", "display_title": "Experimental Factor Ontology", "status": "released", "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "principals_allowed": {"view": ["system.Everyone"], "edit": ["group.admin"]}}], "term_id": "EFO:0003045", "term_url": "http://www.ebi.ac.uk/efo/EFO_0003045", "namespace": "http://www.ebi.ac.uk/efo", "term_name": "H9", "definition": "This human ES cell line expresses cell surface markers specific to undifferentiated nonhuman primate ES and human EC cells: stage-specific embryonic antigen (SSEA)\u20133, SSEA-4, TRA-l-60, TRA-1- 81, and alkaline phosphatase. It has a normal 46, XX karyotype. Teratomas are formed upon cell injection into SCID mice. These teratomas include cells from all three germ layers.\n\nIsolation & Growth Conditions\nThis cell line can be cultured using feeder cells or in a feeder-free protocol. When using feeder cells, human ESC culture medium should be compreised of Advanced DMEM/F12 supplemented with knockout serum replacement (20%), non-essential amino acids (1x), L-glutamine (1x), penicillin/streptomycin (1x), \u03b2-mercaptoethanol (1x) and FGF-2 (4 ng/ml). Maintain the human ESCs on Matrigel using hESC medium conditioned by mouse embryonic fibroblasts. 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